3-Ethyl-4-methylpyridine → 1-(3-Trifluoromethylphenyl)-4-(3-ethyl-4-pyridyl)-butane

HRID 257487

반응식

HRID 257487 반응식
[CH2:1]([C:3]1[CH:4]=[N:5][CH:6]=[CH:7][C:8]=1[CH3:9])[CH3:2].Br[CH2:11][CH2:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([C:20]([F:23])([F:22])[F:21])[CH:15]=1>>[F:21][C:20]([F:22])([F:23])[C:16]1[CH:15]=[C:14]([CH2:13][CH2:12][CH2:11][CH2:9][C:8]2[CH:7]=[CH:6][N:5]=[CH:4][C:3]=2[CH2:1][CH3:2])[CH:19]=[CH:18][CH:17]=1

참가 물질

3

반응물 2

HCID 682543-Ethyl-4-methylpyridineHCID 197833671-(3-Bromopropyl)-3-(trifluoromethyl)benzene

생성물 1

HCID 148837951-(3-Trifluoromethylphenyl)-4-(3-ethyl-4-pyridyl)-butane수율 80.5%

실험 절차

1.83 g (15.1 mmol) of 3-ethyl-4-methylpyridine and 4.03 g (15.1 mmol) of 1-bromo-3-(3-trifluoromethylphenyl) propane were reacted in the same manner as in Example 26. The reaction compound was purified to obtain 3.73 g of the desired compound (yield: 80.5%).

후처리

  1. customThe reaction compound was purified

출처 및 근거

ORD 기록
ord-3b9d8da1be95426a9dea1dec64ae6189
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05262420

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