5-Chloro-1-benzofuran → 5-Chloro-2,3-dihydro-1-benzofuran
반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[CH:7][C:6]=2[CH:10]=1>CCO.[Rh]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH2:8][CH2:7][C:6]=2[CH:10]=1참가 물질
4
실험 절차
5-Chloro-benzofurane (2 g, 13.11 mmol) in dry EtOH (20 ml) was hydrogenated over 10% Rh/C (251 mg) catalyst at room temperature under atmospheric pressure. When H2 absorption ceased the catalyst was filtered off and the filtrate was concentrated in vacuo to give 1.84 g (91%) of (33) as a colourless solid. 1H-NMR (80 MHz, CDCl3) δ 7.00 (d, 2H, J=8.53 Hz), 6.62 (d, 1H, J=8.53), 4.5 (t, 2H), 3.11 (t, 2H).
후처리
- customWhen H2 absorption
- filtrationwas filtered off
- concentrationthe filtrate was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-479282472fb84b2692964152d1140bd8
- 출처 데이터셋
- uspto-grants-1993_11
- 특허 번호
- US05262430
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