Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 4-Benzoyl-2(S)-trifluoroacetamidobutyric acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Ethyl Acetate | HCID 8857 | — |
| 반응물 | N-[(3S)-2,6-dioxooxan-3-yl]-2,2,2-trifluoroacetamide | HCID 2779007 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 용매 | Benzene | HCID 241 | — |
| 생성물 | 4-Benzoyl-2(S)-trifluoroacetamidobutyric acid | HCID 14390810 | — |
반응 단계
Heat at reflux for 3 hours a mixture of N-trifluoroacetyl-L-glutamic anhydride (18.0 g, 80 mmol) and AlCl3 (23.5 g, 177 mmol) in dry benzene (400 ml). Allow to cool, treat with ice (400 ml), conc. HCl (100 ml), and ethyl acetate (EtOAc) (400 ml). Dry the organic layer and concentrate to obtain the title compound as a brown crystalline solid (25 g).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05262436 |
| 출처 데이터셋 | uspto-grants-1993_11 |
| ORD ID | ord-46bd8a2309e340c792f0e0c9cc52a5c5 |
| 출처 메모 | uspto-grants-1993_11 |