Methanol → HCID 15232720, 화합물

HRID 257617노트

반응식

HRID 257617 반응식
[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([OH:28])=[O:27])[O:10][C:11]=2[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:29]O>S(=O)(=O)(O)O.C(OCC)C>[C:1]1([C:7]2[N:8]=[C:9]([CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][C:26]([O:28][CH3:29])=[O:27])[O:10][C:11]=2[C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 2

HCID 887MethanolHCID 1319604,5-Diphenyl-2-oxazolenonanoic acid

생성물 1

HCID 15232720HCID 15232720, 화합물수율 96%

시약·촉매·용매 2

HCID 1118Sulfuric Acid촉매HCID 3283Diethyl Ether용매

실험 절차

A mixture of 4,5-diphenyl-2-oxazole nonanoic acid (800 mg, 2 mmol), methanol (2 mL) and concentrated sulfuric acid (2 drops) was heated to reflux. After 2 hours, the solvent was evaporated and the residue partitioned between CH2Cl2 and water. The organic phase was separated, washed with saturated NaHCO3 solution, dried over sodium sulfate and concentrated in vacuo to leave an oil. Chromatography on a column of silica gel using a mixture of hexanes and diethyl ether (4:1) as eluent gave methyl 4,5-diphenyl-2-oxazolenonanoate (800 mg, 96%).

후처리

  1. temperaturewas heated to reflux
  2. customthe solvent was evaporated
  3. customthe residue partitioned between CH2Cl2 and water
  4. customThe organic phase was separated
  5. washwashed with saturated NaHCO3 solution
  6. dry with materialdried over sodium sulfate
  7. concentrationconcentrated in vacuo
  8. customto leave an oil

출처 및 근거

ORD 기록
ord-78f90e43addb4234ade53f9ce9039d2e
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05262540

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