Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
m-ethylphenyl-N-methylcyanamide → N,N'-di-(m-ethylphenyl)-N-methylguanidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | m-ethylphenyl-N-methylcyanamide | HCID 10103434 | — |
| 반응물 | m-Ethylaniline hydrochloride | HCID 21191493 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | N,N'-di-(m-ethylphenyl)-N-methylguanidine | HCID 178436394 | 56% |
반응 단계
A mixture of N-(m-ethylphenyl)-N-methylcyanamide (640 mg, 4 mmol) and m-ethylaniline hydrochloride (630 mg, 4 mmol) was placed in a preheated oil bath at 160° C. for 2.5 hours and then allowed to cool to room temperature. The resulting solid was taken up in dichloromethane and washed with 10% NAOH solution. The organic layer concentrated and the residue was flash chromatographed on SiO2 to give N,N'-di-(m-ethylphenyl)-N-methylguanidine (630 mg, 56%) as a colorless liquid:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05262568 |
| 출처 데이터셋 | uspto-grants-1993_11 |
| ORD ID | ord-23f092a4d4fd419bad7b04c2d1e3873d |
| 출처 메모 | uspto-grants-1993_11 |