참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Naphthalenamine, hydrochloride (1:1) | HCID 11094 | — |
| 반응물 | N-(m-ethylphenyl)-N-ethylcyanamide | HCID 10442201 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178436371 | HCID 178436371 | 67.2% |
반응 단계
A mixture of N-(m-ethylphenyl)-N-ethylcyanamide (500 mg, 2.86 mmol) and 1-aminonaphthalene hydrochloride (520 mg, 2.86 mmol) was heated in a preheated oil bath at 160° C. for 2 hours and then allowed to cool to room temperature. The resulting solid was taken in dichloromethane and washed with 10% NAOH solution. The organic layer was concentrated and the resulting residue was flash chromatographed on silica gel to give N-(1-naphthyl)-N'-(m-ethylphenyl)-N'-ethylguanidine (610 mg, 67%) as a light brown liquid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05262568 |
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| 출처 데이터셋 | uspto-grants-1993_11 |
|---|
| ORD ID | ord-9d2f7f5125e14daf8c02fc9d13b2b4b8 |
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| 출처 메모 | uspto-grants-1993_11 |
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