Dimethyldioxirane → 1-Hydroxy-2,6-diphenyl-3,5-dimethylpiperidin-4-yl Laurate
반응식
[C:1]([O:14][CH:15]1[CH:20]([CH3:21])[CH:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[NH:18][CH:17]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH:16]1[CH3:34])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].CC1(C)O[O:37]1>>[C:1]([O:14][CH:15]1[CH:16]([CH3:34])[CH:17]([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[N:18]([OH:37])[CH:19]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH:20]1[CH3:21])(=[O:13])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]참가 물질
3
실험 절차
The general procedure of Example 2 is repeated using 29.9 g (64.5 mmol) of 2,6-diphenyl-3,5-dimethylpiperidin-4-yl laurate and 1.24 L (64.5 mmol) of dimethyldioxirane (0.050M in acetone). 30.8 g (98% yield) of the title compound is isolated: mp 108°-112° C.
출처 및 근거
- ORD 기록
- ord-dd0c233a7279440fa75c447a9c74ed5d
- 출처 데이터셋
- uspto-grants-1993_11