Methylparaben → Methyl 4-(allyloxy)benzoate

HRID 257830

반응식

HRID 257830 반응식
[OH:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:18](Br)[CH:19]=[CH2:20]>CC(C)=O>[CH2:20]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([O:8][CH3:9])=[O:7])=[CH:10][CH:11]=1)[CH:19]=[CH2:18]

참가 물질

5

반응물 3

HCID 7456MethylparabenHCID 7841Allyl bromideHCID 11430Potassium Carbonate

생성물 1

HCID 4645407Methyl 4-(allyloxy)benzoate수율 86%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A 2 L flask was equipped with a mechanical stirrer, a reflux condenser and a stopper, then charged with 50.05 g (0.329 mol) of methyl 4-hydroxybenzoate, 960 mL of acetone, 22.50 g (1.625 mol) of anhydrous potassium carbonate, 80.5 mL (112.6 g, 0.932 mol) of allyl bromide and the mixture was stirred and refluxed for 14 hours. The mixture was cooled to room temperature, filtered and concentrated to an oil. The residual oil was purified by distillation (97° C. @ 0.03 mm Hg) to afford 53.52 g (86%) of the title compound.

후처리

  1. customA 2 L flask was equipped with a mechanical stirrer, a reflux condenser
  2. temperaturerefluxed for 14 hours
  3. filtrationfiltered
  4. concentrationconcentrated to an oil
  5. distillationThe residual oil was purified by distillation (97° C. @ 0.03 mm Hg)

출처 및 근거

ORD 기록
ord-964d5f58841d4a3c80a26641e99c4a23
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05264439

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