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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Methyl 2-[4-(aminomethyl)phenoxy]-2-(2-chlorophenyl)acetate → 5-butyl-4-[4-[(1-carbomethoxy)(1-(2-chlorophenyl))methoxy]phenyl]methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

HRID 257846
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HRID 257846 반응식
[C:1]([NH:6][N:7]=[C:8](OCC)[CH2:9][CH2:10][CH2:11][CH3:12])([O:3]CC)=O.[NH2:16][CH2:17][C:18]1[CH:36]=[CH:35][C:21]([O:22][CH:23]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=2[Cl:34])[C:24]([O:26][CH3:27])=[O:25])=[CH:20][CH:19]=1>C(O)C>[CH2:9]([C:8]1[N:16]([CH2:17][C:18]2[CH:36]=[CH:35][C:21]([O:22][CH:23]([C:24]([O:26][CH3:27])=[O:25])[C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=3[Cl:34])=[CH:20][CH:19]=2)[C:1](=[O:3])[NH:6][N:7]=1)[CH2:10][CH2:11][CH3:12]
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참가 물질

4

반응물 2

HCID 19781920Methyl 2-[4-(aminomethyl)phenoxy]-2-(2-chlorophenyl)acetateHCID 53752329Ethyl valerate carbethoxyhydrazone

생성물 1

HCID 197818905-butyl-4-[4-[(1-carbomethoxy)(1-(2-chlorophenyl))methoxy]phenyl]methyl-2,4-dihydro-3H-1,2,4-triazol-3-one

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
80 °C

실험 절차

A mixture of approximately equimolar quantities of ethyl valerimidate carbethoxyhydrazone (from Step A) and methyl 2-[4-(aminomethyl)phenoxy]-2-(2-chlorophenyl)acetate (Step F) in ethanol is stirred at 80° C. under N2. After about 2 hours, or when TLC indicates complete reaction, the mixture is cooled and concentrated to dryness. The residue is re-concentrated from CH2Cl2 and then chromatographed on silica gel to yield the title compound.

후처리

  1. customreaction
  2. temperaturethe mixture is cooled
  3. concentrationconcentrated to dryness
  4. concentrationThe residue is re-concentrated from CH2Cl2
  5. customchromatographed on silica gel

출처 및 근거

ORD 기록
ord-5d3831f9bee3421ca572860631ca2b71
출처 데이터셋
uspto-grants-1993_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05264439

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