Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Bromobenzene → 4-(1-Oxo-4-methyl-pentyl) bromobenzene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Bromobenzene | HCID 7961 | — |
| 반응물 | Isocaproic acid | HCID 12587 | — |
| 반응물 | Aluminum(III) Chloride | HCID 6451240 | — |
| 반응물 | 4-(4-Methylpentyl)-phenylethyne | HCID 15337560 | — |
| 생성물 | 4-(1-Oxo-4-methyl-pentyl) bromobenzene | HCID 22409079 | — |
반응 단계
Reaction Scheme 5 discloses a specific synthetic route to 4-(4-methylpentyl)-phenylethyne (Compound 26). In accordance with this scheme, bromobenzene (Compound 27) is reacted under Friedel Crafts conditions (AlCl3) with the acid chloride (Compound 28) prepared in situ from 4-methyl valeric acid, to yield 4-(1-oxo-4-methyl-pentyl) bromobenzene (Compound 29). Compound 29 is reduced under Wolff-Kishner conditions (KOH, NH2NH2) to yield 4-(4-methylpentyl) bromobenzene (Compound 30). The bromobenzene derivative 30 is converted to the ethyne derivative 26 through the intermediate trimethylsilyl ethyne derivative 31 in a manner similar to the conversion described in connection with Reaction Scheme 3. ##STR9##
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05264456 |
| 출처 데이터셋 | uspto-grants-1993_11 |
| ORD ID | ord-a0740368008340198f0d6daf431e602f |
| 출처 메모 | uspto-grants-1993_11 |