Allyl Mercaptan → 4-Allylsulfanylmethyl-6-dibenzofuran-4-yl-2,2-dimethyl-1,2-dihydroquinoline

HRID 25800

반응식

HRID 25800 반응식
[CH3:1][C:2]1([CH3:21])[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7](OS(C(F)(F)F)(=O)=O)[CH:8]=2)[NH:3]1.[CH:22]1[C:30]2[C:29]3[CH:31]=[CH:32][CH:33]=[CH:34][C:28]=3[O:27][C:26]=2[C:25](B(O)O)=[CH:24][CH:23]=1.[CH2:38]([SH:41])[CH:39]=[CH2:40]>>[CH2:38]([S:41][CH2:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:25]3[C:26]4[O:27][C:28]5[CH:34]=[CH:33][CH:32]=[CH:31][C:29]=5[C:30]=4[CH:22]=[CH:23][CH:24]=3)[CH:8]=2)[NH:3][C:2]([CH3:1])([CH3:21])[CH:11]=1)[CH:39]=[CH2:40]

참가 물질

4

반응물 3

HCID 13367Allyl MercaptanHCID 2734328Dibenzofuran-4-boronic acidHCID 20760320Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester

생성물 1

HCID 100246194-Allylsulfanylmethyl-6-dibenzofuran-4-yl-2,2-dimethyl-1,2-dihydroquinoline

실험 절차

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 4-dibenzofuranboronic acid. Bromination and coupling reaction with allyl mercaptan gave 52 mg of the title compound.

출처 및 근거

ORD 기록
ord-4acca39642214d8c89581f129d323e48
출처 데이터셋
uspto-grants-2005_02
특허 번호
US06858627B2

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