2-Phenylethanethiol → 6-(3-Methoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

HRID 25806

반응식

[CH3:1][C:2]1([CH3:21])[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7](OS(C(F)(F)F)(=O)=O)[CH:8]=2)[NH:3]1.[CH3:22][O:23][C:24]1[CH:25]=[C:26](B(O)O)[CH:27]=[CH:28][CH:29]=1.[C:33]1([CH2:39][CH2:40][SH:41])[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1>>[CH3:22][O:23][C:24]1[CH:25]=[C:26]([C:7]2[CH:8]=[C:9]3[C:4](=[CH:5][CH:6]=2)[NH:3][C:2]([CH3:1])([CH3:21])[CH:11]=[C:10]3[CH2:12][S:41][CH2:40][CH2:39][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[CH:27]=[CH:28][CH:29]=1

참가 물질

반응물 3

HCID 781262-Phenylethanethiol

HCID 2734370(3-Methoxyphenyl)boronic acid

HCID 20760320Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester

생성물 1

HCID 103418076-(3-Methoxyphenyl)-2,2-dimethyl-4-phenethylsulfanylmethyl-1,2-dihydroquinoline

실험 절차

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 3-methoxyphenylboronic acid. Bromination and coupling reaction with 2-phenylethanethiol gave 21 mg of the title compound.

출처 및 근거

ORD 기록: ord-7c56a04383ed4063bf8cdbd4df45e8e4
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06858627B2

연결된 노트

불러오는 중…