Allyl Mercaptan → 4-Allylsulfanylmethyl-6-(5-isopropyl-2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline

HRID 25815

반응식

[CH3:1][C:2]1([CH3:21])[CH:11]=[C:10]([CH3:12])[C:9]2[C:4](=[CH:5][CH:6]=[C:7](OS(C(F)(F)F)(=O)=O)[CH:8]=2)[NH:3]1.[CH:22]([C:25]1[CH:26]=[CH:27][C:28]([O:34][CH3:35])=[C:29](B(O)O)[CH:30]=1)([CH3:24])[CH3:23].[CH2:36]([SH:39])[CH:37]=[CH2:38]>>[CH2:36]([S:39][CH2:12][C:10]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([C:27]3[CH:26]=[C:25]([CH:22]([CH3:24])[CH3:23])[CH:30]=[CH:29][C:28]=3[O:34][CH3:35])[CH:8]=2)[NH:3][C:2]([CH3:1])([CH3:21])[CH:11]=1)[CH:37]=[CH2:38]

참가 물질

반응물 3

HCID 13367Allyl Mercaptan

HCID 45891905-Isopropyl-2-methoxyphenylboronic acid

HCID 20760320Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester

생성물 1

HCID 104082874-Allylsulfanylmethyl-6-(5-isopropyl-2-methoxyphenyl)-2,2-dimethyl-1,2-dihydroquinoline

실험 절차

Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester was coupled with 5-isopropyl-2-methoxyphenylboronic acid. Bromination and coupling reaction with allyl mercaptan gave 25 mg of the title compound.

출처 및 근거

ORD 기록: ord-65bc0f663e534c029eaa0a76da58a392
출처 데이터셋: uspto-grants-2005_02
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06858627B2

연결된 노트

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