Bromine → Methyl 4-bromo-7-methoxy-2H-1,3-benzodioxole-5-carboxylate
반응식
[CH3:1][O:2][C:3]1[C:4]2[O:15][CH2:14][O:13][C:5]=2[CH:6]=[C:7]([CH:12]=1)[C:8]([O:10][CH3:11])=[O:9].[Br:16]Br>C(O)(=O)C>[Br:16][C:6]1[C:5]2[O:13][CH2:14][O:15][C:4]=2[C:3]([O:2][CH3:1])=[CH:12][C:7]=1[C:8]([O:10][CH3:11])=[O:9]참가 물질
4
실험 절차
In 35 ml of acetic acid was dissolved 10.5 g of methyl 5-methoxy-3,4-methylenedioxybenzoate, and a solution of bromine (formed by diluting 8 g of bromine with 25 ml of acetic acid) was dropped into the solution over a period of 1 hour. The mixture was stirred at room temperature for 10 hours and the reaction liquid was poured into ice water, and the formed precipitate was recovered by filtration and recrystallized from ethanol to obtain methyl 2-bromo-5-methoxy-3,4-methylenedioxybenzoate (the yield was 51%).
후처리
- customthe reaction liquid
- filtrationthe formed precipitate was recovered by filtration
- customrecrystallized from ethanol
출처 및 근거
- ORD 기록
- ord-721af72956c94556ae745bc4f58863fa
- 출처 데이터셋
- uspto-grants-1993_11
- 특허 번호
- US05264594
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