Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Catechol | HCID 289 | — |
| 반응물 | Iodine | HCID 807 | — |
| 반응물 | 4-Bromoaniline | HCID 7807 | — |
| 반응물 | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| 생성물 | 6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline | HCID 10729464 | 27% |
반응 단계
4-Bromoaniline (50 g, 0.290 mol), magnesium sulfate (250 g, 2 mol), iodine (2.5 g, 0.01 mol) and catechol (2.24 g, 0.020 mol) were combined in acetone (750 mL) in a sealed-tube reaction flask. The reaction vessel was placed in a pre-equilibrated oil bath set at 125° C. and stirred overnight. The reaction mixture was then cooled to room temperature, filtered over a pad of diatomaceous earth, and concentrated in vacuo. Chromatography on silica gel provided 6-bromo-2,2,4-trimethyl-1,2-dihydroquinoline as tan colored crystals (21 g, 27% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06858627B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-bc6bae7813934b2eac71c44d75ed28f3 |
| 출처 메모 | uspto-grants-2005_02 |