Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Allyl Mercaptan → 4-Allylsulfanylmethyl-6-(2-nitrophenyl)-2,2-dimethyl-1,2-dihydroquinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Allyl Mercaptan | HCID 13367 | — |
| 반응물 | N-bromobutanimide | HCID 67184 | — |
| 반응물 | (2-Nitrophenyl)boronic acid | HCID 2773548 | — |
| 반응물 | 6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline | HCID 10729464 | — |
| 반응물 | Trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester | HCID 20760320 | — |
| 생성물 | 4-Allylsulfanylmethyl-6-(2-nitrophenyl)-2,2-dimethyl-1,2-dihydroquinoline | HCID 10021826 | — |
반응 단계
6-Bromo-2,2,4-trimethyl-1,2-dihydroquinoline was coupled with 2-nitrophenylboronic acid using the procedure described in Example 7 for trifluoromethanesulfonic acid 2,2,4-trimethyl-1,2-dihydroquinolin-6-yl ester. The resulting intermediate was brominated with NBS, followed by the coupling reaction with allyl mercaptan as described in Example 7, to provide 15 mg of the title compound as an oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06858627B2 |
| 출처 데이터셋 | uspto-grants-2005_02 |
| ORD ID | ord-620b59c3289f49d2a64264d11b6dd951 |
| 출처 메모 | uspto-grants-2005_02 |