1-Bromo-4-fluorobenzene → Ethyl 4-(4-fluorophenyl)benzoate

HRID 258268

반응식

HRID 258268 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][CH:3]=1.Br[C:10]1[CH:20]=[CH:19][C:13]([C:14]([O:16][CH2:17][CH3:18])=[O:15])=[CH:12][CH:11]=1>>[CH2:17]([O:16][C:14](=[O:15])[C:13]1[CH:19]=[CH:20][C:10]([C:2]2[CH:7]=[CH:6][C:5]([F:8])=[CH:4][CH:3]=2)=[CH:11][CH:12]=1)[CH3:18]

참가 물질

3

반응물 2

HCID 99931-Bromo-4-fluorobenzeneHCID 22043Ethyl 4-bromobenzoate

생성물 1

HCID 11989650Ethyl 4-(4-fluorophenyl)benzoate

실험 절차

Using the procedure of Example 551, 4-bromofluorobenzene (1.75 g, 10 mmol) was metallated and coupled with ethyl 4-bromobenzoate (2.28 g, 10 mmol) to give the title compound after chromatography (ethyl acetate-hexanes (1:9) (0.7 g)): 1H-NMR (CDCl3, 300 MHz): 8.1 (d, 2H, J=8), 7.65-7.5 (m, 4H), 7.15 (t, 2H, J=8), 4.4 (q, 2H, J=7), 1.4 (t, 3H, J=7); MS:244.

출처 및 근거

ORD 기록
ord-fa57f1e14ca94ca08a48ab8e56403711
출처 데이터셋
uspto-grants-1993_11
특허 번호
US05266572

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