참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Phenol | HCID 996 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | 1-Pentyne, 5-chloro- | HCID 84308 | — |
| 반응물 | (Pent-4-yn-1-yloxy)benzene | HCID 13221461 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Hexane | HCID 8058 | — |
| 용매 | Hexamethylphosphoramide | HCID 12679 | — |
| 생성물 | 4-(5-Phenoxypentyl)benzyl alcohol | HCID 14576782 | 69% |
반응 단계
5-Phenoxypent-1-yne--The process described by the Swiss patent [Chem. Abstr. 93: 167896d) was used. Thus, a mixture of 2.8 g sodium hydride, 5.51 g phenol in 40 mL dry tetrahydrofuran (THF) was stirred at 0° C. under argon until hydrogen evolution ceased. To the resultant solution was added 10 mL dry hexamethylphosphoric triamide (HMPA) followed by a solution containing 5-chloropent-1-yne (4.85 g) in 5 mL THF. The solution was heated at 80° C. for 3 days. The cooled (ambient temperature) mixture was diluted with n-hexane and water. The hexane layer was washed with 2×50 mL portions of water, 1×10 mL 10% potassium carbonate and dried (MgSO4). The evaporated extract was distilled (bp 115°-118° C., 23 mm) to give the title compound (69%) as a colorless oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05266713 |
|---|
| 출처 데이터셋 | uspto-grants-1993_11 |
|---|
| ORD ID | ord-a1bbddceb19a429583d289a3ffad6495 |
|---|
| 출처 메모 | uspto-grants-1993_11 |
|---|
