Dichloromethane → 1,2-Dimethoxy-4-(2-propenyl)-5-(2-cyano-3-methoxy-2-propenyl)benzene

HRID 258559

반응식

HRID 258559 반응식
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:11][CH:12]=[CH2:13])=[CH:7][C:8]=1[O:9][CH3:10].CO[CH:16]([O:21][CH3:22])[C:17](=[CH2:20])[C:18]#[N:19].C(Cl)Cl>CCOCC>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:20][C:17]([C:18]#[N:19])=[CH:16][O:21][CH3:22])[C:6]([CH2:11][CH:12]=[CH2:13])=[CH:7][C:8]=1[O:9][CH3:10]

참가 물질

5

반응물 3

HCID 6344DichloromethaneHCID 7127MethyleugenolHCID 124234392-Dimethoxymethylacrylonitrile

생성물 1

HCID 544449171,2-Dimethoxy-4-(2-propenyl)-5-(2-cyano-3-methoxy-2-propenyl)benzene

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To a solution of 10 g. of methyl eugenol and 8.1 g. of 2-dimethoxymethylacrylonitrile in 200 ml. of dry methylene chloride was added 1.97 ml. of stannic chloride. After stirring for 5 hours at room temperature, 300 ml. of ether was added and the mixture washed with a 5% sodium bicarbonate solution (until basic). The organic layer was dried (MgSO4) and the solvent removed under reduced pressure. The residue was triturated with ether to give 1,2-dimethoxy-4-(2-propenyl)-5-(2-cyano-3-methoxy-2-propenyl)benzene, m.p. 77°-79°.

후처리

  1. washthe mixture washed with a 5% sodium bicarbonate solution (until basic)
  2. dry with materialThe organic layer was dried (MgSO4)
  3. customthe solvent removed under reduced pressure
  4. customThe residue was triturated with ether

출처 및 근거

ORD 기록
ord-b285d52060e248b7bf3f7ddf301c25ec
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04033962

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