Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 2-Amino-5-chloropyridin-3-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Potassium Hydroxide | HCID 14797 | — |
| 반응물 | 3,5-Dichloro-3-pyridylamine | HCID 77886 | — |
| 촉매 | Copper | HCID 23978 | — |
| 용매 | Diglyme | HCID 8150 | — |
| 생성물 | 2-Amino-5-chloropyridin-3-ol | HCID 10313200 | 70% |
반응 단계
A mixture of 20 parts of 2-amino-3,5-dichloropyridine, 160 parts of glycol, 80 parts of potassium hydroxide, 1 part of copper powder and 3 parts of diethylene glycol dimethyl ether is stirred under nitrogen for 5 hours at 150°-160° C. The cooled solution is neutralised with conc. hydrochloric acid, saturated with sodium chloride and extracted twice in the warm state with ethyl acetate. The combined extracts are filtered through Hyflo, dried over magnesium sulphate and purified with active charcoal. The solvent is evaporated off to leave 12.3 parts (70% of theory) of 2-amino-3-hydroxy-5-chloropyridine, m.p. 198°-201° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04033975 |
| 출처 데이터셋 | uspto-grants-1977_07 |
| ORD ID | ord-7b568c3df9f444d6a72ba2742e3cce12 |
| 출처 메모 | uspto-grants-1977_07 |