Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 2-Phenyl-4-(beta-hydroxyethyl)thiazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Ethyl 2-(2-phenyl-1,3-thiazol-4-yl)acetate | HCID 2797666 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | 2-Phenyl-4-(beta-hydroxyethyl)thiazole | HCID 10608315 | — |
반응 단계
Reduction of the latter ester to the title compound is effected as follows: The ester (159 g) is dissolved in dry tetrahydrofuran (250 ml) and added dropwise during 30 min to a stirred mixture of lithium aluminum hydride (50 g) in tetrahydrofuran. The mixture is stirred for one hour, cooled and water (150 ml) is slowly added. The mixture is dried over magnesium sulfate and evaporated to give the title compound as a yellow oil, γmaxCHCl3 3610, 3420 and 1520 cm- 1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04033977 |
| 출처 데이터셋 | uspto-grants-1977_07 |
| ORD ID | ord-5f3d911fa4f342a987c166e3d11b4fc7 |
| 출처 메모 | uspto-grants-1977_07 |