Water → 2-Phenyl-4-(beta-hydroxyethyl)thiazole

HRID 258577

반응식

HRID 258577 반응식
[C:1]1([C:7]2[S:8][CH:9]=[C:10]([CH2:12][C:13](OCC)=[O:14])[N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[C:1]1([C:7]2[S:8][CH:9]=[C:10]([CH2:12][CH2:13][OH:14])[N:11]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 2797666Ethyl 2-(2-phenyl-1,3-thiazol-4-yl)acetateHCID 21226445Aluminium lithium hydride

생성물 1

HCID 106083152-Phenyl-4-(beta-hydroxyethyl)thiazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

Reduction of the latter ester to the title compound is effected as follows: The ester (159 g) is dissolved in dry tetrahydrofuran (250 ml) and added dropwise during 30 min to a stirred mixture of lithium aluminum hydride (50 g) in tetrahydrofuran. The mixture is stirred for one hour, cooled and water (150 ml) is slowly added. The mixture is dried over magnesium sulfate and evaporated to give the title compound as a yellow oil, γmaxCHCl3 3610, 3420 and 1520 cm- 1.

후처리

  1. temperaturecooled
  2. dry with materialThe mixture is dried over magnesium sulfate
  3. customevaporated

출처 및 근거

ORD 기록
ord-5f3d911fa4f342a987c166e3d11b4fc7
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04033977

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