Urea → 4-[2-(Dimethylamino)ethyl]-6,7-dihydro-4-methyl-2-phenyl-4H-pyrano[4,3-d]thiazole

HRID 258584

반응식

HRID 258584 반응식
NC(N)=O.[C:5]1([C:11]2[S:12][CH:13]=[C:14]([CH2:16][CH2:17][OH:18])[N:15]=2)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:19][N:20]([CH2:22][CH2:23][C:24](=O)[CH3:25])[CH3:21]>>[CH3:19][N:20]([CH3:21])[CH2:22][CH2:23][C:24]1([CH3:25])[C:13]2[S:12][C:11]([C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=3)=[N:15][C:14]=2[CH2:16][CH2:17][O:18]1

참가 물질

4

반응물 3

HCID 1176UreaHCID 5469134-(Dimethylamino)butan-2-oneHCID 106083152-Phenyl-4-(beta-hydroxyethyl)thiazole

생성물 1

HCID 124290164-[2-(Dimethylamino)ethyl]-6,7-dihydro-4-methyl-2-phenyl-4H-pyrano[4,3-d]thiazole

실험 절차

By following the procedure of Example 2(a) but using as starting material in Example 2(a) an appropriate starting material of formula II, for example, those described in Examples 2 to 14 and an appropriate aminoketone of formula III in which R2 and n are as described above and A is CH2NR4R5 wherein R4 and R5 are as described above, the amino compounds of formula I listed in Examples 31 to 46 are obtained. For example, according to the present procedure 2-phenyl-4-(β-hydroxyethyl)thiazole condenses with 1-(N,N-dimethylamino)-3-butanone to give the title compound, identical to the amine described in Example 31.

후처리

  1. customare obtained

출처 및 근거

ORD 기록
ord-6d090cda82b94c9da739068a5876079f
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04033977

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