4-Methoxy-2-quinolinecarboxylic acid → HCID 178492678, 화합물

HRID 258669

반응식

HRID 258669 반응식
[CH3:1][O:2][C:3]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:5]([C:6](O)=[O:7])[CH:4]=1.[NH2:16][C:17]1[NH:21][N:20]=[N:19][N:18]=1>CN(C)C=O>[CH3:1][O:2][C:3]1[C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=[C:5]([C:6]([NH:16][C:17]2[NH:21][N:20]=[N:19][N:18]=2)=[O:7])[CH:4]=1

참가 물질

4

반응물 2

HCID 5945964-Methoxy-2-quinolinecarboxylic acidHCID 178509299HCID 178509299, 화합물

생성물 1

HCID 178492678HCID 178492678, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-Methoxyquinaldic acid (7.25 g) was dissolved in dry dimethylformamide (20 ml). N,N'-carbonyldiimidazole (5.8 g) was added, and the solution was stirred for 6 hours at room temperature. 5-Aminotetrazole (3.69 g) was added and the mixture was stirred overnight at room temperature. The solid was filtered off, washed with methanol and dissolved in dimethylformamide (50 ml) with the minimum addition of dimethylaminoethanol to effect dissolution. Water (50 ml) was added, and the solution was adjusted to pH 2 by the addition of aqueous hydrochloric acid. The solid was filtered off to give 4-methoxy-N(1H-tetrazol- 5-yl)quinaldamide, m.p. 289° (d).

후처리

  1. stirringthe mixture was stirred overnight at room temperature
  2. filtrationThe solid was filtered off
  3. washwashed with methanol
  4. dissolutiondissolved in dimethylformamide (50 ml) with the minimum addition of dimethylaminoethanol
  5. dissolutiondissolution
  6. additionWater (50 ml) was added
  7. additionthe solution was adjusted to pH 2 by the addition of aqueous hydrochloric acid
  8. filtrationThe solid was filtered off

출처 및 근거

ORD 기록
ord-71265ad2affa449288b009151d4ae194
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04034075

연결된 노트

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