Hydrazine → 2-Hydrazinyl-5-nitropyridine

HRID 25870

반응식

HRID 25870 반응식
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[NH2:11][NH2:12]>CO.O>[NH:11]([C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1)[NH2:12]

참가 물질

5

반응물 2

HCID 9321HydrazineHCID 783082-Chloro-5-nitropyridine

생성물 1

HCID 40319312-Hydrazinyl-5-nitropyridine

시약·촉매·용매 2

HCID 887Methanol용매HCID 962Water용매

반응 조건

온도
10 °C

실험 절차

To a slurry of 47.6 g (0.3 mol) of 2-chloro-5-nitropyridine in a mixture of 400 ml methanol and 60 ml water and cooled to 10° C. was added with cooling below 30° 86 g hydrazine (95 percent) over about 10 minutes. The solids first went into solution, then a greenish-yellow precipitate separated. The mixture was stirred at reflux for 30 minutes. The greenish solid was filtered off and washed with cold methanol. The solid was slurried in 200 ml of cold water, washed and vacuum dried. The yield was 40.1 g (87 percent).

후처리

  1. additionwas added
  2. customa greenish-yellow precipitate separated
  3. temperatureat reflux for 30 minutes
  4. filtrationThe greenish solid was filtered off
  5. washwashed with cold methanol
  6. washwashed
  7. customvacuum dried

출처 및 근거

ORD 기록
ord-134f974d07114d98b685b018028a437a
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04147544

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