참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrazine Sulfate | HCID 24842 | — |
| 반응물 | Potassium Bicarbonate | HCID 516893 | — |
| 반응물 | HCID 178485010 | HCID 178485010 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | HCID 178485006 | HCID 178485006 | 46.9% |
반응 단계
A mixture of the isothiourea dihydrochloride from Example 1 (i) (8.3 g), hydrazine sulphate (4.1 g), potassium hydrogen carbonate (12.5 g) and anhydrous dimethyl formamide (100 ml) was stirred at 90° C. for 3 hours. Following cooling and filtration from inorganic material, the filtrate containing the free base was treated with ethanolic hydrogen chloride. The residue was then triturated with isopropanol to give a solid which was recrystallised from aqueous isopropanol to give the title compound (1.94 g), m.p. 234°-235°.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04034101 |
|---|
| 출처 데이터셋 | uspto-grants-1977_07 |
|---|
| ORD ID | ord-2179ab7713b242788365fa0853126697 |
|---|
| 출처 메모 | uspto-grants-1977_07 |
|---|
