Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 258745생성일: 2026년 10월 24일
Hydrochloric Acid → N-Methyl-N'-methylamino-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride
https://huagongshe.com/ko/reaction/258745
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Potassium Bicarbonate | HCID 516893 | — |
| 반응물 | N-methyl-N-tert-butoxycarbonylhydrazine sulphate | HCID 88794812 | — |
| 반응물 | HCID 178485010 | HCID 178485010 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N-Methyl-N'-methylamino-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride | HCID 178486240 | — |
반응 단계
A mixture of the isothiourea dihydrochloride of Example 1 (i) (6.7 g), N-methyl-N-tert-butoxycarbonylhydrazine sulphate (5.7 g), potassium hydrogen carbonate (10.0 g) and anhydrous dimethylformamide (80 ml) was stirred at 90° C. for 3 hours. After cooling, filtration and concentration to yield the free base, this was heated under reflux with ethanolic hydrogen chloride. Concentration and trituration of the residual product yielded the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04034101 |
|---|
| 출처 데이터셋 | uspto-grants-1977_07 |
|---|
| ORD ID | ord-ae33860c3be94f0fa9214fab10a9ef6e |
|---|
| 출처 메모 | uspto-grants-1977_07 |
|---|
