Hydrochloric Acid → N-Methyl-N'-methylamino-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride

HRID 258745

반응식

HRID 258745 반응식
[ClH:1].Cl.O[NH:4][C:5]([NH:17][CH3:18])=[N:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16].S(O)(O)(=O)=O.[CH3:24][N:25](C(OC(C)(C)C)=O)N.C(=O)([O-])O.[K+].Cl>CN(C)C=O>[ClH:1].[ClH:1].[CH3:18][NH:17][C:5]([NH:4][NH:25][CH3:24])=[N:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16]

참가 물질

6

반응물 4

HCID 313Hydrochloric AcidHCID 516893Potassium BicarbonateHCID 88794812N-methyl-N-tert-butoxycarbonylhydrazine sulphateHCID 178485010HCID 178485010, 화합물

생성물 1

HCID 178486240N-Methyl-N'-methylamino-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
90 °C

실험 절차

A mixture of the isothiourea dihydrochloride of Example 1 (i) (6.7 g), N-methyl-N-tert-butoxycarbonylhydrazine sulphate (5.7 g), potassium hydrogen carbonate (10.0 g) and anhydrous dimethylformamide (80 ml) was stirred at 90° C. for 3 hours. After cooling, filtration and concentration to yield the free base, this was heated under reflux with ethanolic hydrogen chloride. Concentration and trituration of the residual product yielded the title compound.

후처리

  1. temperatureAfter cooling
  2. filtrationfiltration and concentration
  3. customto yield the free base
  4. temperaturethis was heated
  5. concentrationConcentration and trituration of the residual product

출처 및 근거

ORD 기록
ord-ae33860c3be94f0fa9214fab10a9ef6e
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04034101

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