Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Dimethyl 3-oxoglutarate → Methyl 3-[7-(diethylamino)-2-oxo-2h-chromen-3-yl]-3-oxopropanoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Dimethyl 3-oxoglutarate | HCID 74591 | — |
| 반응물 | 4-(Diethylamino)-2-hydroxybenzaldehyde | HCID 87293 | — |
| 생성물 | Methyl 3-[7-(diethylamino)-2-oxo-2h-chromen-3-yl]-3-oxopropanoate | HCID 3326307 | — |
반응 단계
A solution of 1.93 g 4-diethylaminosalicylaldehyde, 1.80 g. dimethyl 1,3-acetone dicarboxylate in 10 ml. alcohol containing 10 drops piperidine was heated under reflux on a steam bath for 2 hours. After chilling in the freezer, the product was collected and recrystallized from a mixture of alcohol and acetonitrile. Yield 2.6 g (82%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04147552 |
| 출처 데이터셋 | uspto-grants-1979_04 |
| ORD ID | ord-9bb7a49ccb15458eb06d178ed62e3219 |
| 출처 메모 | uspto-grants-1979_04 |