O-propylhydroxylamine → N-methyl-N'-n-butoxy-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride

HRID 258751노트

반응식

HRID 258751 반응식
[ClH:1].Cl.[OH:3][NH:4][C:5]([NH:17][CH3:18])=[N:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16].[CH2:19](ON)[CH2:20][CH3:21].[CH2:24]([O:28][NH2:29])[CH2:25][CH2:26][CH3:27].Cl.Cl.Cl.O[N:34]([CH2:48]CSCC1NC=NC=1C)[C:35](N)=[N:36][CH2:37][CH2:38][S:39][CH2:40][C:41]1[NH:45][CH:44]=[N:43][C:42]=1[CH3:46]>>[ClH:1].[ClH:1].[CH3:18][NH:17][C:5]([NH:4][O:3][CH2:19][CH2:20][CH3:21])=[N:6][CH2:7][CH2:8][S:9][CH2:10][C:11]1[NH:15][CH:14]=[N:13][C:12]=1[CH3:16].[ClH:1].[ClH:1].[CH3:48][NH:34][C:35]([NH:29][O:28][CH2:24][CH2:25][CH2:26][CH3:27])=[N:36][CH2:37][CH2:38][S:39][CH2:40][C:41]1[NH:45][CH:44]=[N:43][C:42]=1[CH3:46]

참가 물질

6

반응물 4

HCID 2768918O-propylhydroxylamineHCID 3014370O-ButylhydroxylamineHCID 178433318HCID 178433318, 화합물HCID 178485010HCID 178485010, 화합물

생성물 2

HCID 178454581N-methyl-N'-n-butoxy-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochlorideHCID 178460301N-methyl-N'-n-propoxy-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride

실험 절차

Reaction of the isothiourea dihydrochloride of Example 1 (i) with n-propoxyamine and n-butyoxyamine according to the procedure of Example 1 (ii) gave respectively N-methyl-N'-n-propoxy-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride and N-methyl-N'-n-butoxy-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidine dihydrochloride.

출처 및 근거

ORD 기록
ord-692b49d5bc2641e8962ebf0e7e328df1
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04034101

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