Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Hydroxy-4-Methoxybenzaldehyde → 3-Nicotinoyl-7-methoxycoumarin
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Hydroxy-4-Methoxybenzaldehyde | HCID 69600 | — |
| 반응물 | Ethyl 3-oxo-3-(pyridin-3-yl)propanoate | HCID 222197 | — |
| 촉매 | Piperidine | HCID 8082 | — |
| 생성물 | 3-Nicotinoyl-7-methoxycoumarin | HCID 21217331 | — |
반응 단계
A mixture of 0.65 g ethyl nicotinoylacetate, 0.5 g 2-hydroxyanisaldehyde and 10 ml alcohol was heated on a steam bath until solution was attained. Five drops of piperdine were added and heating was continued. After several minutes the reaction mixture solidified. An additional 10 ml of alcohol were added and the reaction mixture heated another 15 minutes. After cooling, the solid was collected and recrystallized twice from a mixture of alcohol and acetonitrile.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04147552 |
| 출처 데이터셋 | uspto-grants-1979_04 |
| ORD ID | ord-0df72b8e35584857b395332273362433 |
| 출처 메모 | uspto-grants-1979_04 |