2-Hydroxy-4-Methoxybenzaldehyde → 3-Nicotinoyl-7-methoxycoumarin

HRID 25876

반응식

HRID 25876 반응식
[C:1]([CH2:9][C:10]([O:12][CH2:13][CH3:14])=[O:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.O[C:16]1C=[C:22]([O:24][CH3:25])[CH:21]=[CH:20][C:17]=1C=O>N1CCCCC1>[C:1]([C:9]1[C:10](=[O:11])[O:12][C:13]2[C:17]([CH:16]=1)=[CH:20][CH:21]=[C:22]([O:24][CH3:25])[CH:14]=2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1

참가 물질

4

반응물 2

HCID 696002-Hydroxy-4-MethoxybenzaldehydeHCID 222197Ethyl 3-oxo-3-(pyridin-3-yl)propanoate

생성물 1

HCID 212173313-Nicotinoyl-7-methoxycoumarin

시약·촉매·용매 1

HCID 8082Piperidine촉매

실험 절차

A mixture of 0.65 g ethyl nicotinoylacetate, 0.5 g 2-hydroxyanisaldehyde and 10 ml alcohol was heated on a steam bath until solution was attained. Five drops of piperdine were added and heating was continued. After several minutes the reaction mixture solidified. An additional 10 ml of alcohol were added and the reaction mixture heated another 15 minutes. After cooling, the solid was collected and recrystallized twice from a mixture of alcohol and acetonitrile.

후처리

  1. temperaturewas heated on a steam bath until solution
  2. temperatureheating
  3. waitAfter several minutes the reaction mixture solidified
  4. temperaturethe reaction mixture heated another 15 minutes
  5. temperatureAfter cooling
  6. customthe solid was collected
  7. customrecrystallized twice from a mixture of alcohol and acetonitrile

출처 및 근거

ORD 기록
ord-0df72b8e35584857b395332273362433
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04147552

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