Acefylline → HCID 86734928, 화합물

HRID 258811

반응식

HRID 258811 반응식
[CH:1](=[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][NH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N:18]1([C:29](=[O:30])[C:28]2[N:27]([CH2:31][C:32]([OH:34])=[O:33])[CH:26]=[N:25][C:24]=2[N:22]([CH3:23])[C:20]1=[O:21])[CH3:19]>C(O)CC>[CH:1](=[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH2:11][CH2:10][NH2+:9]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1.[N:18]1([C:29](=[O:30])[C:28]2[N:27]([CH2:31][C:32]([O-:34])=[O:33])[CH:26]=[N:25][C:24]=2[N:22]([CH3:23])[C:20]1=[O:21])[CH3:19]

참가 물질

4

반응물 2

HCID 69550AcefyllineHCID 70634238HCID 70634238, 화합물

생성물 1

HCID 86734928HCID 86734928, 화합물수율 48%

시약·촉매·용매 1

HCID 10311-Propanol용매

실험 절차

2.21 g. (0.01 mole) of 1-benzal-1,2,3,4-tetrahydroisoquinoline and 2.38 g. (0.01 mole) of theophylline-7-acetic acid are dissolved under boiling in 25 ml. of n-propanol. The undissolved substances is filtered from the hot solution. The clear filtrate is crystallized while the mixture is cooled. The precipitated crystals are filtered out, covered with n-propanol and dried at room temperature. Thus 2.2 g. of 1-benzal-1,2,3,4-tetrahydroisoquinolinium-theophylline-7-acetate yield 48%) are obtained. Mp.: 168°-173° C. After recrystallization from a twofold amount of n-propanol the melting point was 195°-198° C.

후처리

  1. filtrationThe undissolved substances is filtered from the hot solution
  2. customThe clear filtrate is crystallized while the mixture
  3. temperatureis cooled
  4. filtrationThe precipitated crystals are filtered out
  5. customdried at room temperature

출처 및 근거

ORD 기록
ord-d139aa97146b4758aebd90d098d8954c
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04035366

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