Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl Isobutyl Ketone → 1-(3-chloropropyl)-2-(methylthio)-1H-benzimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl Isobutyl Ketone | HCID 7909 | — |
| 반응물 | 1-Bromo-3-chloropropane | HCID 8006 | — |
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 2-(Methylthio)benzimidazole | HCID 23539 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 1-(3-chloropropyl)-2-(methylthio)-1H-benzimidazole | HCID 13564028 | 50% |
반응 단계
A mixture of 8.2 parts of 2-(methylthio)-1H-benzimidazole, 16 parts of 1-bromo-3-chloropropane, 5.3 parts of sodium carbonate and 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 44 hours. After cooling, water is added and the layers are separated. The organic phase is dried, filtered and evaporated. The residue is stirred in 2,2'-oxybispropane. The unreacted starting material is filtered off and the filtrate is evaporated, yielding 6 parts (50%) of 1-(3-chloropropyl)-2-(methylthio)-1H-benzimidazole as an oily residue.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04035369 |
| 출처 데이터셋 | uspto-grants-1977_07 |
| ORD ID | ord-694125e3bfad4e168ff476ac012846e7 |
| 출처 메모 | uspto-grants-1977_07 |