Water → HCID 178514091, 화합물

HRID 258991

반응식

HRID 258991 반응식
Cl.[NH2:2][C@H:3]([C:6](O)=O)[CH2:4][SH:5].Br[CH2:10][CH2:11][NH:12][C:13]([NH2:15])=[O:14].[OH2:16]>>[NH:12]([CH2:11][CH2:10][CH2:6][C@@H:3]([C:4]([OH:16])=[S:5])[NH2:2])[C:13]([NH2:15])=[O:14]

참가 물질

4

반응물 3

HCID 962Water3회HCID 60960Cysteine HydrochlorideHCID 2636101-(2-Bromoethyl)urea

생성물 1

HCID 178514091HCID 178514091, 화합물

반응 조건

온도
50 °C

실험 절차

26.25 g of cysteine hydrochloride and 27.83 g of β-bromoethylurea are dissolved in 150 cc of water under nitrogen. A solution of 13.35 g of soda in 30 cc of water is added during a 40 minute period and the mixture is heated for 3 hours at 50° C. After cooling, there is added to the solution, four times its volume of water and the resulting mixture is passed over a cation exchange resin. After washing with water, the product fixed on the resin is eluted with an ammoniacal solution. The eluate is evaporated to dryness and the residue is crystallized in an aqueous methanol solution. There are obtained 19.5 grams of the white product melting at 220° C with decomposition.

후처리

  1. temperatureAfter cooling
  2. washAfter washing with water
  3. washis eluted with an ammoniacal solution
  4. customThe eluate is evaporated to dryness
  5. customthe residue is crystallized in an aqueous methanol solution

출처 및 근거

ORD 기록
ord-36c24f6c62de4ceeaa705f3de9047a49
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04035492

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