Chlorine → Maltol

HRID 25906

반응식

HRID 25906 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]([OH:8])[CH3:7].Cl[O-:10].[Na+].ClCl>O1CCCC1.O>[CH3:7][C:6]1[O:8][CH:5]=[CH:4][C:3](=[O:10])[C:2]=1[OH:1]

참가 물질

6

반응물 3

HCID 24526ChlorineHCID 1072431-(2-Furyl)ethanolHCID 23665760Sodium Hypochlorite

생성물 1

HCID 8369Maltol

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of 1(2-furyl)-1-ethanol (0.05 mole) in 15 ml of tetrahydrofuran and 15 ml of water at 5° C. is added 21.7 ml of 2.8 M sodium hypochlorite solution. Chlorine (0.05 mole) is added to the reaction flask via a gas inlet tube maintaining the reaction temperature below 5° C. The reaction mixture is then heated to reflux and the tetrahydrofuran removed by distillation. Heating is continued for an additional hour. The reaction mixture is cooled and maltol is isolated by the procedure described in Example 1.

후처리

  1. temperaturemaintaining the reaction temperature below 5° C
  2. temperatureThe reaction mixture is then heated
  3. temperatureto reflux
  4. customthe tetrahydrofuran removed by distillation
  5. temperatureHeating
  6. waitis continued for an additional hour
  7. temperatureThe reaction mixture is cooled

출처 및 근거

ORD 기록
ord-09e8b01cef48419b8f8d5e7670f29be6
출처 데이터셋
uspto-grants-1979_04
특허 번호
US04147705

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