Ethanol → Ethyl 4-decylpiperazine-1-carboxylate

HRID 259066노트

반응식

HRID 259066 반응식
CS(O[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])(=O)=O.[CH2:16]([O:18][C:19]([N:21]1[CH2:26][CH2:25][NH:24][CH2:23][CH2:22]1)=[O:20])[CH3:17].C(O)C.C(=O)([O-])[O-].[K+].[K+]>O.C(OCC)C>[CH2:16]([O:18][C:19]([N:21]1[CH2:22][CH2:23][N:24]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[CH2:25][CH2:26]1)=[O:20])[CH3:17]

참가 물질

7

반응물 4

HCID 702EthanolHCID 84311-Piperazinecarboxylic acid, ethyl esterHCID 11430Potassium CarbonateHCID 5235508Decyl methanesulfonate

생성물 1

HCID 228932Ethyl 4-decylpiperazine-1-carboxylate

시약·촉매·용매 2

HCID 962Water용매HCID 3283Diethyl Ether용매

실험 절차

77.3 Grams of decyl methylsulfonate, 44.64 grams of 1-ethoxycarbonylpiperazine, 500 ml. of ethanol, and 39 grams of potassium carbonate are combined and refluxed for approximately 44 hours under a nitrogen atmosphere. After cooling to room temperature the residue is dissolved in a mixture of water and ethyl ether. The organic layer is separated, washed three times with portions of water and dried over anhydrous sodium sulfate. The solvents are removed under reduced pressure to give 1-ethoxycarbonyl-4-decylpiperazine.

후처리

  1. temperaturerefluxed for approximately 44 hours under a nitrogen atmosphere
  2. customThe organic layer is separated
  3. washwashed three times with portions of water
  4. dry with materialdried over anhydrous sodium sulfate
  5. customThe solvents are removed under reduced pressure

출처 및 근거

ORD 기록
ord-2ab7a268626c4c259e68ae53ac0c746c
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04036828

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