Dimethylamine → 1,1-Dimethyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea
반응식
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]([N:10]=[C:11]=[O:12])[CH2:7][CH2:8][CH2:9][C:2]1=2.[CH3:13][NH:14][CH3:15]>C(OCC)C>[CH3:13][N:14]([CH3:15])[C:11]([NH:10][CH:6]1[C:3]2[CH:4]=[CH:5][S:1][C:2]=2[CH2:9][CH2:8][CH2:7]1)=[O:12]참가 물질
4
실험 절차
A solution of 6.27 grams of 4,5,6,7-tetrahydrobenzo[b]thien-4-yl isocyanate in 200 ml. of diethyl ether is charged with gaseous dimethylamine introduced via a capillary tube with stirring. After 0.5 hour of bubbling, the gas flow is terminated, and the mixture is evaporated to dryness to give a solid residue. This is crystallized from acetone-hexane-ether to give 1,1-dimethyl-3-(4,5,6,7-tetrahydrobenzo[b]thien-4-yl)urea melting at 117° C. to 120° C.
후처리
- additionintroduced via a capillary tube
- customAfter 0.5 hour of bubbling
- customthe gas flow is terminated
- customthe mixture is evaporated to dryness
- customto give a solid residue
- customThis is crystallized from acetone-hexane-ether
출처 및 근거
- ORD 기록
- ord-ced409063f364945a642ce72b14c391e
- 출처 데이터셋
- uspto-grants-1977_07
- 특허 번호
- US04036979
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