1-Aminohydantoin → alpha-[[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]benzeneacetic acid, ethyl ester

HRID 259390

반응식

HRID 259390 반응식
[NH2:1][N:2]1[CH2:6][C:5](=[O:7])[NH:4][C:3]1=[O:8].[N:9]([CH:12]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[C:10]=[O:11]>O1CCOCC1>[O:8]=[C:3]1[NH:4][C:5](=[O:7])[CH2:6][N:2]1[NH:1][C:10]([NH:9][CH:12]([C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[C:13]([O:15][CH2:16][CH3:17])=[O:14])=[O:11]

참가 물질

4

반응물 2

HCID 728231-AminohydantoinHCID 56982438alpha-Isocyanatobenzeneacetic acid, ethyl ester

생성물 1

HCID 86734963alpha-[[[(2,4-Dioxo-1-imidazolidinyl)amino]carbonyl]amino]benzeneacetic acid, ethyl ester

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

1.15 g. (0.01 mol.) of 1-amino-2,4-dioxoimidazolidine are dissolved in 50 ml. of dioxane while heating. The solution is permitted to cool to room temperature while stirring, wherein a portion of the 1-amino-2,4-dioxoimidazolidine crystallizes out. 2.05 g. (0.01 mol.) of α-isocyanatobenzeneacetic acid, ethyl ester are added and the reation mixture is stirred overnight at room temperature. On the next day the mixture is concentrated and the residue is triturated with ether. 3.0 g. of α-[[[(2,4-dioxo-1-imidazolidinyl)amino]-carbonyl] amino]benzeneacetic acid, ethyl ester are obtained, m.p. 148°-151°.

후처리

  1. customwherein a portion of the 1-amino-2,4-dioxoimidazolidine crystallizes out
  2. stirringthe reation mixture is stirred overnight at room temperature
  3. concentrationOn the next day the mixture is concentrated
  4. customthe residue is triturated with ether

출처 및 근거

ORD 기록
ord-5135711ffbba467f97cb00c6db5a74f4
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04038271

연결된 노트

불러오는 중…