Potassium Hydroxide → 4-Ethoxy-2-methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

HRID 259408노트

반응식

HRID 259408 반응식
Cl.[CH2:2]([O:4][C:5]1[C:6]2[C:7](=[N:16][N:17]([CH3:19])[CH:18]=2)[N:8]=[CH:9][C:10]=1[C:11]([O:13]CC)=[O:12])[CH3:3].[OH-].[K+]>C(O)C>[CH2:2]([O:4][C:5]1[C:6]2[C:7](=[N:16][N:17]([CH3:19])[CH:18]=2)[N:8]=[CH:9][C:10]=1[C:11]([OH:13])=[O:12])[CH3:3]

참가 물질

4

반응물 2

HCID 14797Potassium HydroxideHCID 92019408HCID 92019408, 화합물

생성물 1

HCID 214217464-Ethoxy-2-methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

28.5 g. of 4-ethoxy-2 -methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid, ethyl ester, hydrochloride from Example 2 and 15 g. of potassium hydroxide are refluxed in 100 ml. of ethanol for 10 hours. The solvent is then distilled off and the residue is dissolved in 20 ml. of water. Acetic acid is added and a precipitate of 16 g. of 4-ethoxy-2-methyl-2H-pyrazolo[3,4-b]pyridine-5-carboxylic acid; m.p. 222°-225° (DMF); is obtained.

후처리

  1. distillationThe solvent is then distilled off
  2. dissolutionthe residue is dissolved in 20 ml
  3. additionAcetic acid is added
  4. customis obtained

출처 및 근거

ORD 기록
ord-6a3dd96a877940e3b5f88e5709f88c0d
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04038283

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