Ammonia → 4,5-Dimethoxy-2-methylbenzene-1-sulfonamide

반응식

[S:1](Cl)([OH:4])(=O)=[O:2].[CH3:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][CH:8]=1.[NH3:17]>>[CH3:6][C:7]1[CH:12]=[C:11]([O:13][CH3:14])[C:10]([O:15][CH3:16])=[CH:9][C:8]=1[S:1]([NH2:17])(=[O:4])=[O:2]

참가 물질

반응물 2

HCID 222Ammonia

HCID 214222402-Methyl-4,5-dimethoxy-benzene sulfochloride

생성물 1

HCID 352990334,5-Dimethoxy-2-methylbenzene-1-sulfonamide

실험 절차

18 gm (0.07 mol) of the compound obtained in step (a) were suspended in 200 ml of concentrated ammonia, and the suspension was stirred at room temperature for 4 hours. Thereafter, the mixture was suction-filtered, the filter cake was washed with water, and the desired sulfonamide was obtained as an amorphous product after drying. Rf -value (benzene/acetone = 1/1): 0.6.

후처리

filtrationThereafter, the mixture was suction-filtered
washthe filter cake was washed with water

출처 및 근거

ORD 기록: ord-7d5928546b9b4978a1ec81d729dc8835
출처 데이터셋: uspto-grants-1977_07
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04038407

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