Benzene → 2,5-Diphenyloxazolo[5,4-b]pyridine

HRID 259555

반응식

HRID 259555 반응식
N[C:2]1[N:7]=[C:6]2[O:8][C:9]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)=[N:10][C:5]2=[CH:4][CH:3]=1.[N+]([O-])(OCCC(C)C)=O.[CH:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1>>[C:11]1([C:9]2[O:8][C:6]3[C:5]([N:10]=2)=[CH:4][CH:3]=[C:2]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[N:7]=3)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

참가 물질

4

반응물 3

HCID 241BenzeneHCID 10985Isoamyl nitrateHCID 227547935-Amino-2-phenyloxazolo[5,4-b]pyridine

생성물 1

HCID 156656752,5-Diphenyloxazolo[5,4-b]pyridine

실험 절차

A mixture of 180 mg. of 5-amino-2-phenyloxazolo[ 5,4-b]pyridine, 10 ml. of benzene and 0.2 ml. of isoamyl nitrate was refluxed for 11/2 hours. The hot solution was filtered and concentrated to dryness. The residue was extracted with ether and the extract was filtered through aluminum oxide and concentrated to dryness. The crystalline residue was recrystallized from ethyl acetate to give 2,5-diphenyloxazolo[ 5,4-b]pyridine, m.p. 151°-152° C.

후처리

  1. additionA mixture of 180 mg
  2. filtrationThe hot solution was filtered
  3. concentrationconcentrated to dryness
  4. extractionThe residue was extracted with ether
  5. filtrationthe extract was filtered through aluminum oxide
  6. concentrationconcentrated to dryness
  7. customThe crystalline residue was recrystallized from ethyl acetate

출처 및 근거

ORD 기록
ord-b544000962be4351a3834cd683a82c26
출처 데이터셋
uspto-grants-1977_07
특허 번호
US04038396

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