Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Chlorophenol → 1-Phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Chlorophenol | HCID 4684 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | 1-Bromo-3,3-dimethyl-1-phenylbutan-2-one | HCID 13458693 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-Phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one | HCID 21326028 | 67% |
반응 단계
A solution of 25.4 g (0.1 mole) of 1-bromo-1-phenyl-3,3-dimethyl-butan-2-one in 50 ml of ethyl acetate was added dropwise, at the boil, to a solution of 12.85 g (0.1 mole) of 4-chlorophenol and 2.3 g (0.1 mole) of sodium in 100 ml of ethanol. After boiling for 12 hours under reflux, the sodium bromide which had separated out was filtered off hot. The filtrate was distilled in vacuo and the solid residue which remained was recrystallized from ligroin. 20.2 g (67% of theory) of 1-phenyl-1-(4'-chlorophenoxy)-3,3-dimethyl-butan-2-one of melting point 103° C. were obtained.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04147791 |
| 출처 데이터셋 | uspto-grants-1979_04 |
| ORD ID | ord-2a6191e666fa47fc92c5b3dc0bd416f8 |
| 출처 메모 | uspto-grants-1979_04 |