2,6-Dimethylquinoline → 4-[2,6-Dimethyl-1quinolinio]butanesulfonate

HRID 259667

반응식

HRID 259667 반응식
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:12])[CH:8]=2)[N:3]=1.[CH2:13]1[S:18](=[O:20])(=[O:19])[O:17][CH2:16][CH2:15][CH2:14]1>CC(C)=O>[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH3:12])[CH:8]=2)[N+:3]=1[CH2:16][CH2:15][CH2:14][CH2:13][S:18]([O-:20])(=[O:19])=[O:17]

참가 물질

4

반응물 2

HCID 134142,6-DimethylquinolineHCID 154111,4-Butane sultone

생성물 1

HCID 867484494-[2,6-Dimethyl-1quinolinio]butanesulfonate수율 94.3%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

After 72.3 g (0.46 mol) of 2,6-dimethylquinoline and 188 g (1.4 mol) of butane sultone were heated at 145° C. with stirring for 4 hours, the mixture was allowed to cool to room temperature, and 500 ml of acetone was added thereto. While cooling, crystallization was conducted for 30 minutes. The resulting crystal was recovered by filtration, washed with acetone and dried to obtain 127.3 g (yield: 94%) of 4-[2,6-dimethyl-1-quinolinio]butane sulfonate.

후처리

  1. temperatureWhile cooling
  2. customcrystallization
  3. waitwas conducted for 30 minutes
  4. filtrationThe resulting crystal was recovered by filtration
  5. washwashed with acetone
  6. customdried

출처 및 근거

ORD 기록
ord-d88cf0498c8c43d8ae8b81cd2e99a3fd
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05523203

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