Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-Benzyl-4-piperidone → N~1~-(1-Benzylpiperidin-4-yl)-N~2~-phenylethane-1,2-diamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-Benzyl-4-piperidone | HCID 19220 | — |
| 반응물 | 1,2-Ethanediamine, N1-phenyl- | HCID 74270 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 용매 | Hydrochloric Acid | HCID 313 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | N~1~-(1-Benzylpiperidin-4-yl)-N~2~-phenylethane-1,2-diamine | HCID 20540168 | — |
반응 단계
To the solution of 12.6 g of N-phenylethylenediamine in 200 ml of methanol, 50 ml of 4.1 N ethanolic hydrogen chloride are added dropwise followed by 18.9 g of 1-benzyl-4-piperidone in 100 ml of methanol. Then, 9.45 g sodium cyanoborohydride are added in portions while stirring at room temperature. After 72 hours the mixture is filtered, the residue dissolved in water and the solution made basic with 12.5% aqueous sodium hydroxide. It is extracted with methylene chloride, dried and evaporated to yield the 1-benzyl-4-(2-phenylaminoethylamino)-piperidine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04147786 |
| 출처 데이터셋 | uspto-grants-1979_04 |
| ORD ID | ord-e571c060f05d484fa41ce6089969dd32 |
| 출처 메모 | uspto-grants-1979_04 |