Acetyl chloride → 1-(Azocan-1-yl)ethan-1-one

HRID 259751노트

반응식

HRID 259751 반응식
[CH2:1]([N:3]([CH2:6][CH3:7])[CH2:4][CH3:5])[CH3:2].C(Cl)(=[O:10])C.O1C[CH2:15][CH2:14][CH2:13]1>>[C:1]([N:3]1[CH2:6][CH2:7][CH2:15][CH2:14][CH2:13][CH2:5][CH2:4]1)(=[O:10])[CH3:2]

참가 물질

4

반응물 3

HCID 6367Acetyl chlorideHCID 8028Tetrahydrofuran2회HCID 8471Triethylamine

생성물 1

HCID 134292821-(Azocan-1-yl)ethan-1-one

실험 절차

To a stirred solution of heptamethyleneimine (5.56 ml; 44 mmol) and triethylamine (6.13 ml; 44 mmol) in tetrahydrofuran (20 ml) under nitrogen at 0° C. was added dropwise a solution of acetyl chloride (3.13 ml; 44 retool) in tetrahydrofuran (20 ml). The reaction mixture was then warmed to room temperature and stirred for 1 hr. The resulting solid was filtered off and washed thoroughly with ether. The filtrate was evaporated in vacuo to give an orange oil. Distillation in vacuo gave the title compound (D9).

후처리

  1. filtrationThe resulting solid was filtered off
  2. washwashed thoroughly with ether
  3. customThe filtrate was evaporated in vacuo
  4. customto give an orange oil
  5. distillationDistillation in vacuo

출처 및 근거

ORD 기록
ord-81e31281b4be49f29f927bbb73481f98
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05523299

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