Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Formamide → 5-chloro-6-methyl-1H-pyrimidin-4-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Formamide | HCID 713 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | Methyl 3-amino-2-chloro-2-butenoate | HCID 76224675 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | 5-chloro-6-methyl-1H-pyrimidin-4-one | HCID 178433212 | — |
반응 단계
25.9 g (0.17 mol) of methyl 3-amino-2-chloro-2-butenoate are reacted with 11.7 g (0.26 mol) of formamide and 51 ml of sodium methylate solution in 20 ml of methanol and worked up in analogy to Example 9 (reaction time 20 h). Yield: 16.6 g (67.5%)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05523404 |
| 출처 데이터셋 | uspto-grants-1996_06 |
| ORD ID | ord-58ad2a4fdb2f4d9bb1f83c2c5786fa1f |
| 출처 메모 | uspto-grants-1996_06 |