Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(2,6-Dimethoxyphenyl)ethanone → Methyl 4-(2,6-dimethoxyphenyl)-4-oxido-2-oxo-3-butenoate sodium salt
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(2,6-Dimethoxyphenyl)ethanone | HCID 16267 | — |
| 반응물 | Sodium | HCID 5360545 | — |
| 반응물 | Sodium Methoxide | HCID 10942334 | — |
| 반응물 | Ethanedioic acid, monoethyl ester | HCID 21943339 | — |
| 용매 | Methanol | HCID 887 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | Methyl 4-(2,6-dimethoxyphenyl)-4-oxido-2-oxo-3-butenoate sodium salt | HCID 70245405 | — |
반응 단계
A solution of 100 g of 2,6-dimethoxyacetophenone and 7.5 ml of ethyl oxalate in 520 ml of anhydrous MeOH is added slowly to a solution of sodium methylate prepared from 12.7 g of sodium and 285 ml of anhydrous MeOH. The reaction mixture is heated to reflux for 7 hours and left overnight at RT. It is poured into 2 liters of iso ether and left stirring for minutes. The expected product is obtained by filtration, washing with iso ether and drying under vacuum, m=120 g, m.p.=178° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05523455 |
| 출처 데이터셋 | uspto-grants-1996_06 |
| ORD ID | ord-f2232b314c4f4f0c8f5f35546d456b8e |
| 출처 메모 | uspto-grants-1996_06 |