1-Benzhydrylamino-1-(4-acetamidophenyl)-methanephosphonous acid → 1-Amino-1-(4-acetamidophenyl)-methanephosphonous acid
반응식
C([NH:14][CH:15]([C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:28])[CH3:27])=[CH:21][CH:20]=1)[P:16]([OH:18])[OH:17])(C1C=CC=CC=1)C1C=CC=CC=1.C(NC(P(O)O)C(C)C)(C1C=CC=CC=1)C1C=CC=CC=1>>[NH2:14][CH:15]([C:19]1[CH:24]=[CH:23][C:22]([NH:25][C:26](=[O:28])[CH3:27])=[CH:21][CH:20]=1)[P:16]([OH:18])[OH:17]참가 물질
3
실험 절차
The procedure described in Example 36B was repeated using DL-1-benzhydrylamino-1-(4-acetamidophenyl)-methanephosphonous acid instead of DL-1-benzhydrylamino-2-methylpropanephosphonous acid to give DL-1-amino-1-(4-acetamidophenyl)-methanephosphonous acid. This was treated with dilute hydrobromic acid at reflux followed by propylene oxide to give DL-1-amino-1-(4-aminophenyl)-methanephosphonous acid.
출처 및 근거
- ORD 기록
- ord-1b3bf3e916bf4ae0856777c878bf7a05
- 출처 데이터셋
- uspto-grants-1979_04
- DOI