Sulfuric Acid → 2,3,4,5-Tetrafluorobenzoic acid

HRID 259957

반응식

HRID 259957 반응식
C[O:2][C:3](=[O:14])[C:4]1[CH:9]=[C:8]([F:10])[C:7]([F:11])=[C:6]([F:12])[C:5]=1[F:13].S(=O)(=O)(O)O>O>[F:13][C:5]1[C:6]([F:12])=[C:7]([F:11])[C:8]([F:10])=[CH:9][C:4]=1[C:3]([OH:14])=[O:2]

참가 물질

4

반응물 2

HCID 1118Sulfuric AcidHCID 600996Methyl 2,3,4,5-tetrafluorobenzoate

생성물 1

HCID 2975492,3,4,5-Tetrafluorobenzoic acid수율 92%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Into a 300 ml three necked flask, 20 g (0.096 mol) of the 2,3,4,5-tetrafluorobenzoic acid-methyl ester prepared in Example 15 and 40 g of 70 wt % sulfuric acid were charged, and the mixture was reacted for 10 hours at 140° C. with stirring. Then, 100 ml of water was added to the reaction solution, and the mixture was left to cool. Then, the mixture was extracted with hot toluene. Then, the solvent was distilled off to obtain 17.1 g of 2,3,4,5-tetrafluorobenzoic acid. The yield was 92%.

후처리

  1. customthe mixture was reacted for 10 hours at 140° C.
  2. waitthe mixture was left
  3. temperatureto cool
  4. extractionThen, the mixture was extracted with hot toluene
  5. distillationThen, the solvent was distilled off

출처 및 근거

ORD 기록
ord-34c15b7a62cc4ce48cdb45ab2349b326
출처 데이터셋
uspto-grants-1996_06
특허 번호
US05523476

연결된 노트

불러오는 중…